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Glutathione has been shown to reduce in neurons and the peripheral blood with people living with Parkinsons which could contribute to the degeneration of dopaminergic neuronal cells in the Substantia nigra [1, 2]

Conversely, enriching the gut microbiota with fiber-fermenting bacteria increases SCFA production and has protective effects: SCFAs signal through receptors like GPR43/GPR109A on immune cells to suppress NF-B activation and induce Tregs [70]

This study systematically delineates the molecular underpinnings of cuproptosis and provides a comprehensive overview of the mechanisms underlying its pivotal role in the pathogenesis of WD

Kamble, S